#
Intrinsic and extrinsic contributions to noise in gene expression

**Shev MacNamara
**

Centre for Mathematical Biology

The Mathematical Institute

University of Oxford

Oxford, England

### Abstract:

Stochastic models for molecular cell biology will be described. A
major focus is the comparison of Monte Carlo and deterministic
algorithms for the chemical master equation. A discussion of the
different contributions to total noise in gene expression from
different sources, notably intrinsic and extrinsic sources, will be
given. Finally, some applications of these models to cellular
oscillators and to immunology will be presented.

An introduction to this subject is

Daniel T. Gillespie, Exact stochastic simulation of coupled chemical reactions,
J. Phys. Chem., 1977, 81 (25), pp 2340-2361, paper