Intrinsic and extrinsic contributions to noise in gene expression

Shev MacNamara
Centre for Mathematical Biology
The Mathematical Institute
University of Oxford
Oxford, England


Stochastic models for molecular cell biology will be described. A major focus is the comparison of Monte Carlo and deterministic algorithms for the chemical master equation. A discussion of the different contributions to total noise in gene expression from different sources, notably intrinsic and extrinsic sources, will be given. Finally, some applications of these models to cellular oscillators and to immunology will be presented.

An introduction to this subject is
Daniel T. Gillespie, Exact stochastic simulation of coupled chemical reactions, J. Phys. Chem., 1977, 81 (25), pp 2340-2361, paper