Tommaso Mazza
Mendel Institute, Rom
Italy
Cancer can be considered as an uncountable noise, which disturbs the normal physiological functioning of a living being. It is a multifactorial, largely unknown, redundant, stable and self-sustaining parasite-like organoid that manages to modify the genome, transcriptome, epigenome and proteome of a hosting organism to survive, even at the cost of killing the host.
Mechanisms for cancer to make a fruitful micro-environment were partly captured and understood by measuring static and dynamic properties of graph data structures, reverse-engineered from real omics-data. This talk will try to shed light on techniques to reconstruct omics-networks starting from real data as well as to pinpoint the (set of) key-molecules that drive the most important biological pathways that cancer plays with to its advantage, but that personalized medicine may hit to rescue the healthy biomolecular behaviors.