Hidden Markov models for genotype phasing and handwritten text alignment

Carl Nettelblad
TDB, Department of Information Technology
Uppsala University


Abstract:

While there are more recent forms of statistical models for complex stochastic processes, hidden Markov models are still useful in many fields. I will discuss two applications, for analyzing the transmission of genetic material between parents and offspring, and a nascent collaboration with Vi2 regarding using a hidden Markov model as a "proofreading" stage when identifying words in written text. In addition, I will mention why you would want to solve a small ODE in a modification of the expectation-maximization (EM) parameter estimation algorithm.